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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HLTF
All Species:
14.24
Human Site:
S194
Identified Species:
24.1
UniProt:
Q14527
Number Species:
13
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q14527
NP_003062.2
1009
113929
S194
G
S
G
R
A
G
P
S
Y
S
M
P
V
H
A
Chimpanzee
Pan troglodytes
XP_001138277
1009
113822
S194
G
S
G
R
A
G
P
S
Y
S
M
P
A
H
A
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_534300
1106
124184
S293
G
S
G
R
A
G
P
S
Y
S
M
P
V
H
A
Cat
Felis silvestris
Mouse
Mus musculus
Q6PCN7
1003
113298
S194
G
S
G
R
A
G
P
S
Y
S
R
P
A
H
V
Rat
Rattus norvegicus
NP_001099948
974
110023
P173
K
H
G
F
K
L
G
P
T
P
K
T
V
G
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508504
884
99044
N163
S
E
K
E
P
P
E
N
V
L
G
G
I
L
A
Chicken
Gallus gallus
Frog
Xenopus laevis
NP_001090145
999
112576
N190
F
R
L
G
P
I
P
N
S
S
Q
L
G
Y
G
Zebra Danio
Brachydanio rerio
XP_693071
942
104740
L180
Q
T
S
L
G
R
D
L
L
G
L
S
T
K
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P34739
1061
118357
S214
E
T
P
I
E
I
L
S
S
T
D
D
D
A
T
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_786706
1093
121576
Q240
I
R
K
M
Y
P
H
Q
K
Q
A
L
H
W
M
Poplar Tree
Populus trichocarpa
XP_002308876
799
88908
I78
P
L
I
D
S
N
M
I
N
V
E
G
I
V
P
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9FF61
881
98598
T160
A
K
L
E
A
S
S
T
V
K
S
T
I
S
R
Baker's Yeast
Sacchar. cerevisiae
P31244
790
91412
K69
K
S
P
D
D
D
D
K
D
F
I
I
D
L
T
Red Bread Mold
Neurospora crassa
Q7S1P9
1222
137173
G250
V
G
A
F
G
V
E
G
W
A
T
R
S
G
T
Conservation
Percent
Protein Identity:
100
99.5
N.A.
85.5
N.A.
83.6
81.4
N.A.
71.7
N.A.
64.3
53.1
N.A.
21.1
N.A.
N.A.
34.5
Protein Similarity:
100
99.8
N.A.
88
N.A.
89.7
87.9
N.A.
78.5
N.A.
79.3
69.8
N.A.
41.2
N.A.
N.A.
53.1
P-Site Identity:
100
93.3
N.A.
100
N.A.
80
13.3
N.A.
6.6
N.A.
13.3
0
N.A.
6.6
N.A.
N.A.
0
P-Site Similarity:
100
93.3
N.A.
100
N.A.
80
20
N.A.
20
N.A.
26.6
13.3
N.A.
20
N.A.
N.A.
0
Percent
Protein Identity:
33.6
N.A.
N.A.
36
22.7
25.2
Protein Similarity:
50.4
N.A.
N.A.
52.7
40.9
43.9
P-Site Identity:
0
N.A.
N.A.
6.6
6.6
0
P-Site Similarity:
13.3
N.A.
N.A.
20
13.3
13.3
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
0
8
0
36
0
0
0
0
8
8
0
15
8
29
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
15
8
8
15
0
8
0
8
8
15
0
0
% D
% Glu:
8
8
0
15
8
0
15
0
0
0
8
0
0
0
0
% E
% Phe:
8
0
0
15
0
0
0
0
0
8
0
0
0
0
0
% F
% Gly:
29
8
36
8
15
29
8
8
0
8
8
15
8
15
8
% G
% His:
0
8
0
0
0
0
8
0
0
0
0
0
8
29
0
% H
% Ile:
8
0
8
8
0
15
0
8
0
0
8
8
22
0
0
% I
% Lys:
15
8
15
0
8
0
0
8
8
8
8
0
0
8
0
% K
% Leu:
0
8
15
8
0
8
8
8
8
8
8
15
0
15
8
% L
% Met:
0
0
0
8
0
0
8
0
0
0
22
0
0
0
8
% M
% Asn:
0
0
0
0
0
8
0
15
8
0
0
0
0
0
0
% N
% Pro:
8
0
15
0
15
15
36
8
0
8
0
29
0
0
8
% P
% Gln:
8
0
0
0
0
0
0
8
0
8
8
0
0
0
0
% Q
% Arg:
0
15
0
29
0
8
0
0
0
0
8
8
0
0
8
% R
% Ser:
8
36
8
0
8
8
8
36
15
36
8
8
8
8
8
% S
% Thr:
0
15
0
0
0
0
0
8
8
8
8
15
8
0
22
% T
% Val:
8
0
0
0
0
8
0
0
15
8
0
0
22
8
8
% V
% Trp:
0
0
0
0
0
0
0
0
8
0
0
0
0
8
0
% W
% Tyr:
0
0
0
0
8
0
0
0
29
0
0
0
0
8
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _